Poor Response [62]

Inadequate response to treatment

Ensure adequate dose of antipsychotic has been tried over sufficient time to allow response

Inadequate response despite adequate trial of antipsychotic	Consider possible causes: Comorbid substance misuse Poor Treatment adherence Physical Illness		Treat co-existing problems

	Consider further psychological intervention		CBT or family interventions: For more than 6 months with more than 10 planned

	Consider trial of olanzapine or risperidone for 6-8 weeks if not tried previously

	Inadequate Response	Consider Trial Clozapine

		Inadequate response to full trial	Full assessment and treatment review

			Very cautiously consider trial of additional antipsychotic combined with clozapine	Consider further psychological intervention